NR4A1 knockdown confers hepatoprotection against ischaemia‐reperfusion injury by suppressing TGFβ1 via inhibition of CYR61/NF‐κB in mouse hepatocytes
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چکیده
منابع مشابه
Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD.
BACKGROUND/AIMS Hypoxia/reoxygenation (H/R) causes oxidative stress to the cell and induces apoptotic cell death. Signal transducer and activator of transcription-3 (Stat3) is one of the most important molecules involved in the initiation of liver development and regeneration, and has recently been shown to protect cells against various pathogens. In order to investigate the hepatoprotective ef...
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Nuclear receptor subfamily 4 group A member 1 (NR4A1), a downstream target of CREB that is a key regulator of epileptogenesis, has been implicated in a variety of biological processes and was previously identified as a seizure-associated molecule. However, the relationship between NR4A1 and epileptogenesis remains unclear. Here, we showed that NR4A1 protein was predominantly expressed in neuron...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2021
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.16493